Deliverables

Del No Title Lead Beneficiary Del Date
D12.1 H – Requirement No. 1 FTELE 31 Jan 2019
D10.1 Minutes of the Kick-Off Meeting FTELE 31 Mar 2019
D11.1 UPGRADE dissemination plan FTELE 31 Mar 2019
D11.2 Website and intranet portal FTELE 31 Mar 2019
D10.2 Release of the Data Management plan FTELE 30 Jun 2019
D1.5 ISOR mutagenesis TUD 31 Dec 2019
D2.1 Genome retargeted LV integrases UPF 31 Dec 2019
D5.1 LV phagocytosis assay FTELE 31 Dec 2019
D11.3 First report on networking, public engagement and communication activities FTELE 31 Dec 2019
D11.8 Plan for exploitation of results FTELE 31 Dec 2019
D10.3 Minutes of the first Annual Meeting FTELE 29 Feb 2020
D1.4 Improved epigenetic editing tools FTELE 30 Jun 2020
D12.2 A – Requirement No. 3 FTELE 30 Jun 2020
D12.4 EPQ – Requirement No. 5 FTELE 30 Jun 2020
D12.5 GEN – Requirement No. 6 FTELE 30 Jun 2020
D1.6 Nanopore Sequencing TUD 31 Dec 2020
D2.3 Proof-of-concept of HITI in the retina FTELE 31 Dec 2020
D2.4 Proof-of-concept of HITI in the liver FTELE 31 Dec 2020
D5.2 Anti-AAV immunity UN NANTES 31 Dec 2020
D5.3 Phagocytosis-resistant LV in vivo FTELE 31 Dec 2020
D5.4 Pre-existing anti-Cas9 immunity in vitro UN NANTES 31 Dec 2020
D11.4 Second report on networking, public engagement and communication activities FTELE 31 Dec 2020
D12.3 A – Requirement No. 4 FTELE 31 Jan 2021
D10.4 Minutes of the second Annual Meeting FTELE 28 Feb 2021
D6.5 Model of human HSC mobilization/depletion in mice FTELE 30 Jun 2021
D1.1 Improved CRISPR/Cas tools UNITN 31 Dec 2021
D2.2 Site-specific LV insertion UPF 31 Dec 2021
D3.2 Assay to detect off-target activity SSR TUD 31 Dec 2021
D3.3 Assay to detect donor template integration UPF 31 Dec 2021
D3.4 Assay to detect chromosomal rearrangements MGH 31 Dec 2021
D4.1 LV with a retargeted tissue tropism UPF 31 Dec 2021
D4.2 Optimized VEsiCas production UNITN 31 Dec 2021
D4.3 AMP based on synthetic carriers LMU 31 Dec 2021
D4.4 AMP based on lipoplexes LMU 31 Dec 2021
D5.5 Tolerogenic strategies for anti-AAV immunity UN NANTES 31 Dec 2021
D5.6 Pre-existing anti-Cas9 immunity in vivo UN NANTES 31 Dec 2021
D5.7 Anti-inflammatory CRISPR/Cas LMU 31 Dec 2021
D6.3 Selection strategy for edited HSPCs FTELE 31 Dec 2021
D6.4 Clonality assessment of edited HSPCs FTELE 31 Dec 2021
D7.1 Editing of the DM1 locus in muscle VUB 31 Dec 2021
D9.3 LV transduction of liver stem cells FTELE 31 Dec 2021
D9.4 Stability of LV transduction FTELE 31 Dec 2021
D11.5 Third report on networking, public engagement and communication activities FTELE 31 Dec 2021
D10.5 Minutes of the third Annual Meeting FTELE 28 Feb 2022
D1.3 New procedure to enhance gene editing UNITN 31 Dec 2022
D1.7 SSR characterization TUD 31 Dec 2022
D2.5 Safe-harbor SSR TUD 31 Dec 2022
D3.5 Specificty profile of epigenome editing FTELE 31 Dec 2022
D6.2 Enhanced engraftment and/or self-renewal of edited HSPCs FTELE 31 Dec 2022
D7.2 Silencing of the p16 gene in muscle UPF 31 Dec 2022
D7.3 Reactivation of the Atg5 gene in muscle UPF 31 Dec 2022
D8.1 hRHO reconstitution upon HITI in the retina FTELE 31 Dec 2022
D8.2 Effects of hRHO reconstitution FTELE 31 Dec 2022
D8.3 mRho editing by VEsiCas delivery UNITN 31 Dec 2022
D9.1 HITI in MPS VI mice FTELE 31 Dec 2022
D9.2 HITI in hemophilic mice VUB 31 Dec 2022
D9.5 LDL-R gene transfer FTELE 31 Dec 2022
D9.6 Epigenetic silencing of Pcsk9 FTELE 31 Dec 2022
D11.6 Fourth report on networking, public engagement and communication activities FTELE 31 Dec 2022
D10.6 Minutes of the fourth Annual Meeting FTELE 28 Feb 2023
D1.2 Novel high-fidelity Cas variants UNITN 31 Dec 2023
D1.8 Mathematical modelling TUD 31 Dec 2023
D3.1 Specificity profile of genome editing tools MGH 31 Dec 2023
D4.5 Non-viral tissue-targeted AMP LMU 31 Dec 2023
D5.8 Tolerogenic strategies for anti-AAV immunity in NHP UN NANTES 31 Dec 2023
D5.9 Tolerogenic strategies for anti-Cas9 immunity UN NANTES 31 Dec 2023
D5.10 Low-immunogenic CRISPR/Cas LMU 31 Dec 2023
D6.1 Improved genome editing protocols in HSPCs FTELE 31 Dec 2023
D6.6 Matched enhancement to biological conditioning strategies FTELE 31 Dec 2023
D10.7 Minutes of the final Meeting FTELE 31 Dec 2023
D11.7 Final report on communication activities FTELE 31 Dec 2023
D11.9 Report on the exploitation of results FTELE 31 Dec 2023